Aneta Petkova
Assistant Professor
Education
PhD Brandeis University (2000)Research Group
Biological PhysicsResearch Interest
My research interests are in experimental biophysics, in particular protein folding and especially amyloid folding. My group will be using solid state nuclear magnetic resonance and other spectroscopic techniques to study membrane and amyloid-forming peptides and proteins.Selected Publications
Petkova A.T., Leapman R.D., Guo Z., Yau W.-M., Mattson M.P., and Tycko R. (2005), “Self-propagating, molecular-level polymorphism in Alzheimer’s ß-amyloid fibrils.” Science 307, 262-265.Petkova A.T., Buntkowsky G., Dyda F., Leapman R.D., Yau W.-M., and Tycko R. (2004), "Solid state NMR reveals a pH-dependent antiparallel ?-sheet registry in fibrils formed by a ß-amyloid peptide.” J. Mol. Biol. 335, 247-260.
Petkova A.T., Ishii Y., Balbach J.J., Antzutkin O.N., Leapman R.D., and Tycko R. (2002), “A structural model for Alzheimer’s ß-amyloid fibrils based on experimental constraints from solid state NMR.” Proc. Natl. Acad. Sci. U.S.A. 99, 16742-16747.
Petkova A.T., and Tycko R. (2002), “Sensitivity enhancement in structural measurements by solid state NMR through pulsed spin locking.” J. Magn. Reson. 155, 293-299.
Petkova A.T., Hu J.G., Bizounok M., Simpson M., Griffin R.G., and Herzfeld J. (1999), “Arginine activity in the proton-motive photocycle of bacteriorhodopsin: solid-state NMR studies of the wild-type and D85N proteins.” Biochemistry 38, 1562-1572.
Baldus M., Petkova A.T., Herzfeld J., and Griffin R.G. (1998), “Cross polarization in the tilted frame: assignment and spectral simplification in heteronuclear spin systems.” Mol. Phys. 95, 1197-1207.