Selected Publications:
Kinetics of folding and binding of an intrinsically disordered protein: the inhibitor of yeast aspartic proteinase YPrA, Ranjani Narayanan, Omjoy K. Ganesh, Arthur S. Edison, Stephen J. Hagen, J. Am. Chem. Soc. (2008) (in press) ASAP Article, 10.1021/ja803221c .
Kinetics of internal-loop formation in polypeptide chains: A simulation study, Dana Doucet, Adrian Roitberg, Stephen J. Hagen, Biophysical Journal 92 2281-2289 (2007)
Probe-dependent and non-exponential relaxation kinetics: Unreliable signatures of downhill protein folding, Stephen J. Hagen, Proteins 68 205-217 (2007).
Characterizing the Residue Level Folding of the Intrinsically Unstructured IA3, Omjoy Ganesh, Terry Green, Arthur S. Edison, and Stephen J. Hagen, Biochemistry (2006) 45, 13585-13596.
Do protein molecules unfold in a simple shear flow?, Juan Jaspe and Stephen J. Hagen, Biophysical Journal (2006) 91, 3415-3424. doi:10.1529/biophysj.106.089367.
Diffusional limits to the speed of protein folding: fact or friction? Stephen J. Hagen, Linlin Qiu, & Suzette A. Pabit, J. Phys. Cond. Matt., (2005) 17, S1503-S1514. DOI
Protein folding: defining a standard set of experimental conditions and a preliminary kinetic data set of two-state proteins, Maxwell, K.L., Wildes, D., Zarrine-Afsar, A., de los Rios, M.A., Brown, A.G., Friel, C.T, Hedberg, L., Horng, J-C., Bona, D., Miller, E.J., Valle-Blisle, A., Main, E.R.G., Bemporad, F., Qiu, L., Teilum, K., Vu, N.-D., Edwards, A.M., Ruczinski, I., Poulsen, F.M., Kragelund, B.B., Michnick, S.W., Chiti, F., Bai, Y., Hagen, S.J., Serrano, L., Oliveberg, M., Raleigh, D.P., Wittung-Stafshede, P., Radford, S.E., Jackson, S.E., Sosnick, T.R., Marqusee, S., Davidson, A.R., Plaxco, K.W. Prot. Sci., 14 602-616 (2005).
Internal friction controls the speed of protein folding from a compact configuration, S.A. Pabit, H. Roder, and S.J. Hagen, Biochemistry, 43, 12532-12538 (2004).
Internal friction in the ultrafast folding of the Tryptophan Cage, Linlin Qiu and S.J. Hagen, Chem. Phys. (Special issue: The Physics of Protein Folding and Function), 307 243-249 (2004). doi:10.1016/j.chemphys.2004.12.002
(Book Review) Biological Physics: Energy Information, Life, by P. Nelson, S.J. Hagen, American Journal of Physics, 72 1359-1360 (2004).
A limiting speed for protein folding at low solvent viscosity , Linlin Qiu and S.J. Hagen, J. Am Chem. Soc., 126 3398-3399 (2004).
IA3, an aspartic proteinase inhibitor from Saccharomyces cerevisiae, is intrinsically unstructured in solution, T. Green, O. Ganesh, K. Perry, L. Smith, L.H. Phylip, T.M. Logan, S.J. Hagen, B.M. Dunn, and A.S. Edison, Biochemistry, DOI: 10.1021/bi034823n (2004).
Tryptophan Zipper Folding Kinetics via Molecular Dynamics and Temperature-Jump Spectroscopy, Christopher D. Snow, Linlin Qiu, Deguo Du, Feng Gai, Stephen J. Hagen, and Vijay S. Pande, Proc. Natl. Acad. Sci. USA, DOI 10.1073/pnas.0305260101 (2004).
Fast chain contraction during protein folding: "Foldability" and collapse dynamics, L. Qiu, C. Zachariah, and S.J. Hagen, Phys. Rev. Lett., 90 (16) (2003). [DOI 10.1103/PhysRevLett.90.168103] . Also indexed in Virtual Journal of Biological Physics Research, 5 (9) May 1, 2003.
Exponential kinetics in 'downhill' protein folding, S.J. Hagen, Proteins: Structure, Function, Genetics, 50, 1-4 (2003).
Smaller and faster: The 20-residue Trp-cage folds in 4 microseconds, L.L. Qiu, S.A. Pabit, A.E. Roitberg, & S.J. Hagen, J. Am. Chem. Soc. Communications, 124, 12952-12953 (2002) [DOI 10.1021/ja0279141].
A laminar-flow fluid mixer for fast fluorescence kinetics studies, S.A. Pabit & S.J. Hagen, Biophysical Journal, 83, 2872-2878 (2002).
Rapid intrachain binding of His-26 and His-33 to heme in unfolded ferrocytochrome c, S.J. Hagen, R.F. Latypov, D.A. Dolgikh, & H. Roder, Biochemistry, 41, 1372-1380 (2002).
Rate of intrachain contact formation in an unfolded protein: temperature and denaturant effects, S.J. Hagen, C.W. Carswell, & E.M. Sjolander, J. Mol. Biol., 305, 1161-1171 (2001).
Two-state expansion and collapse of a polypeptide, S.J. Hagen & W.A. Eaton, J. Mol. Biol. 301, 1037-1045 (2000).
Fast kinetics and mechanisms in protein folding, Eaton WA, Munoz V, Hagen SJ, Jas GS, Lapidus LJ, Henry ER, & Hofrichter J, Ann. Rev. Biophys. Biomolec. Struct., 29, 327-359 (2000).
Rate of intrachain diffusion of unfolded cytochrome-c, S.J. Hagen, J. Hofrichter, & W.A. Eaton, J. Phys. Chem. B 101, 2352 (1997).
Diffusion-limited contact formation in unfolded cytochrome-c: estimating the maximum rate of protein folding, S.J. Hagen, J. Hofrichter, A. Szabo, & W.A. Eaton, Proc. Natl. Acad. Sci. USA 93, 11615 (1996). [See also Commentary on this work by J.A. McCammon, Proc. Natl. Acad. Sci. USA 93, 11426 (1996).]
Geminate rebinding and conformational dynamics of myoglobin embedded in a glass at room temperature, S.J. Hagen, J. Hofrichter, & W.A. Eaton, J. Phys. Chem. 100, 12008 (1996).
Fast Events in Protein Folding, W.A. Eaton, P.A. Thompson, C.-K. Chan, S.J. Hagen, & J. Hofrichter, Structure 4, 1133 (1996).
Non-exponential structural relaxations in proteins, S.J. Hagen & W.A. Eaton, J. Chem. Phys. 104, 3395 (1996).
Protein reaction kinetics in a room-temperature glass, S.J. Hagen, J. Hofrichter, & W.A. Eaton, Science 269, 959 (1995).
Comments on the physics and chemistry of trehalose as a storage medium for hemoglobin-based blood substitutes: 'From Kramers Theory to the Battlefield', S.J. Hagen, H.J. Hofrichter, H.F. Bunn, & W.A. Eaton, TCB 6, 423 (1995).
Handedness: basic physics, S.J. Hagen, Science (letter) 265, 1792 (1994).
Asymmetric current-voltage characteristics in type-II superconductors, X. Jiang, P.J. Connolly, S.J. Hagen, & C.J. Lobb, Phys. Rev. B 49, 9244 (1994).
Anomalous normal state magnetothermopower of electron-doped Nd1.85Ce0.15CuO4+d crystal, W. Jiang, X.Q. Xu, S.J. Hagen, J.L Peng, Z.Y. Li, & R.L. Greene, J. Supercond. 7, 773 (1994).
Hall effect in the mixed state of Nd1.85Ce0.15CuO4-d, A.W. Smith, S.J. Hagen, M. Rajeswari, J.L. Peng, Z.Y. Li, R.L. Greene, S.N. Mao, X.X. Xi, S. Bhattacharya, Q. Li, & C.J. Lobb, Physica B, Part 2 194, 2257 (1994).
Effects of dimensional crossover on anisotropic pinning behavior in a model high Tc superconductor (YBCO/Y1-xPrxBCO superlattices), Q. Li, C. Kwon, X.X. Xi, S. Bhattacharya, A. Walkenhorst, T. Venkatesan, S.J. Hagen, W. Jiang, & R.L. Greene, Physica B, Part 2 194, 2389 (1994).
Anomalous flux-flow Hall effect: Nd1.85Ce0.15CuO4-y and evidence for vortex dynamics, S.J. Hagen, A.W. Smith, M. Rajeswari, J.L. Peng, Z.Y. Li, R.L. Greene, S.N. Mao, X.X. Xi, S. Bhattacharya, Q. Li & C.J. Lobb, Phys. Rev. B 47, 1064 (1993).
Anisotropic normal-state magnetothermopower of superconducting Nd1.85Ce0.15CuO4-y crystals, Wu Jiang, X.Q. Xu, S.J. Hagen, J.L. Peng, Z.Y. Li, & R.L. Greene, Phys. Rev. B 48, 657 (1993).
Hall effect studies of Y1-xPrxBa2Cu3O7 crystals, W. Jiang, J.L. Peng, S.J. Hagen, & R.L. Greene, Phys. Rev. B 46, 8694 (1992).
Thermoelectric power of Nd2-xCexCuO4 crystals, X.Q. Xu, S.J. Hagen, W. Jiang, J.L. Peng, Z.Y. Li, & R.L. Greene, Phys. Rev. B 45, 7356 (1992).
Transport and localization in Nd2-xCexCuO4-y crystals at low doping, S.J. Hagen, X.Q. Xu, W. Jiang, J.L. Peng, Z.Y. Li, & R.L. Greene, Phys. Rev. B 45, 515 (1992).
Effects of dimensional crossover on flux pinning in a model high-Tc superconductor: YBa2Cu3O7/(PrxY1-x)Ba2Cu3O7 superlattices, Q. Li, C. Kwon, X.X. Xi, S. Bhattacharya, A. Walkenhorst, T. Venkatesan, S.J. Hagen, W. Jiang, & R.L. Greene, Phys. Rev. Lett. 69, 2713 (1992).
Hall and Nernst effect studies of vortex motion in Tl2Ba2CaCu2O8, S.J. Hagen, C.J. Lobb, R.L. Greene, & M. Eddy, Physica C 185-189, 1769 (1991).
In-plane transport properties of single-crystal Nd2-xCexCuO4, S.J. Hagen, X.Q. Xu, J.L. Peng, Z.Y. Li, W. Jiang, & R.L. Greene, Physica C 185-189, 1275 (1991).
Effect of stress along the ab plane on the Jc and Tc of YBa2Cu3O7thin films, G.L. Belenky, S.M. Green, A. Roytburd, C.J. Lobb, S.J. Hagen, R.L. Greene, M.G. Forrester, & J. Talvacchio, Phys. Rev. B 44, 10117 (1991).
In-plane transport properties of single-crystal R2-xCexCuO4-y (R=Nd,Sm), S.J. Hagen, J.L. Peng, Z.Y. Li, & R.L. Greene, Phys. Rev. B 43, 13606 (1991).
Flux-flow Hall effect in superconducting Tl2Ba2CaCu2O8 films, S.J. Hagen, C.J. Lobb, R.L. Greene, & M. Eddy, Phys. Rev. B 43, 6246 (1991).
Phonon density of states in Pr2-xCexCuO4 and Pr2CuO4, I.W. Sumarlin, J.W. Lynn, D.A. Neumann, J.J. Rush, J.L. Peng, Z.Y. Li, & S.J. Hagen, Physica C, Part 4 184, 2571 (1991).
Flux-flow Nernst effect in epitaxial YBa2Cu3O7, S.J. Hagen, C.J. Lobb, R.L. Greene, M.G. Forrester, & J. Talvacchio, Phys. Rev. B 42, 6777 (1990).
Anomalous Hall effect in superconductors near their critical temperatures, S.J. Hagen, C.J. Lobb, R.L. Greene, M.G. Forrester, & J.H. Kang, Phys. Rev. B 41, 11630 (1990).
Anisotropy of the thermal conductivity of YBa2Cu3O7, S.J. Hagen, Z.Z. Wang, & N.P. Ong, Phys. Rev. B 40, 9389 (1989).
Approaching the Mott-Hubbard insulator in the 85-K superconductor Bi2(Sr,Ca)3Cu2O8+d by doping with Tm, J. Clayhold, S.J. Hagen, N.P. Ong, J.M. Tarascon, & P. Barboux, Phys. Rev. B 39, 7320 (1989).
Chain-site versus plane-site Cu substitution in YBa2Cu3-xMxO7 (M=Co,Ni): Hall and thermopower studies, J. Clayhold, S. Hagen, Z.Z. Wang, N.P. Ong, J.M. Tarascon, & P. Barboux, Phys. Rev. B 39, 777 (1989).
Andreev reflection, thermal conductivity, torque magnetometry, and Hall effect studies on high-Tc systems, N.P. Ong, T.W. Jing, Z.Z. Wang, J. Clayhold, S.J. Hagen, & T.R. Chien, in Strong Correlation and Superconductivity: Proceedings of the IBM Japan International Symposium, Mt. Fuji, Japan, 1989. Springer Verlag (Berlin 1989), p. 204.
Anomalous in-plane paraconductivity in single-crystal YBa2Cu3O7, S.J. Hagen, Z.Z. Wang, & N.P. Ong, Phys. Rev. B 38, 7137 (1988).
Optical anisotropy of YBa2Cu3O7, I. Bozovic, K. Char, S.J.B. Yoo, A. Kapitulnik, M.R. Beasley, T.H. Geballe, Z.Z. Wang, S. Hagen, N.P. Ong, D.E. Aspnes, & M.K. Kelly, Phys. Rev. B 38, 5077 (1988).
Out-of-plane conductivity in single-crystal YBa2Cu3O7, S.J. Hagen, T.W. Jing, Z.Z. Wang, J. Horvath, & N.P. Ong, Phys. Rev. B 37, 7928 (1988).
Transport and tunneling studies on single crystals of YBa2Cu3O7, N.P. Ong, Z.Z. Wang, S. Hagen, T.W. Jing, J. Clayhold, & J. Horvath, Proceedings of the International Conference on High-Temperature Superconductors and Materials and Mechanisms of Superconductivity -Interlaken, Switzerland, 1988, ed. J. Muller and J.L. Olsen, Physica C 153-155, 1072 (1988).
Experimental search for a heavy neutrino in the beta spectrum of 35S, T. Altzitzoglou, F. Calaprice, M. Dewey, M. Lowry, L. Piilonen, J. Brorsen, S. Hagen, & F. Loeser, Phys. Rev. Lett. 55, 799 (1985).